After a crushing 67-run defeat in the first T20, Ireland showed considerable resolve to seal a memorable win that goes with their dramatic victory in the recent ODI series.
They were much more disciplined with the ball in a topsy-turvy innings for the tourists.
Openers and Beaumont and Bryony Smith got England off to a flying start, reaching 44-0 at the end of the powerplay.
Two quick wickets from Arlene Kelly stymied England’s momentum, with Smith dismissed for 28 and Seren Smale falling for 10.
But Paige Scholfield and Beaumont put on 59 for the third wicket to wrestle the momentum back England’s way.
Ireland hit back once more as Scholfield and Beaumont fell in quick succession, before Prendergast bowled Hollie Armitage for a golden duck to leave England wobbling on 137-5.
Georgia Adams, in just her second T20 international, then hit 23 from just 15 deliveries as England scrambled their way up to 169-8.
Like on Saturday, Ireland lost opener Hunter in the first over of their reply. But rather than triggering a collapse, Prendergast and Lewis showed composure to slowly take the game away from England.